In-Depth Articles
Detailed scientific explanations of eating timing mechanisms
This collection presents comprehensive explorations of physiological processes underlying time-restricted eating patterns. Each article examines specific mechanistic aspects—circadian alignment, hormonal dynamics, metabolic substrate switching, cellular renovation processes—through evidence-based scientific frameworks.
Featured Articles
Circadian Alignment and Metabolic Responses to Meal Timing
Comprehensive overview of chronobiology principles, circadian rhythm properties, and metabolic synchronisation with feeding windows. Explores how timing relative to the internal biological clock influences hormonal secretion and energy substrate utilisation.
Read the full scientific explanationHormonal Dynamics Across Fasting and Feeding Windows
Detailed exploration of endocrine system responses across the fasting-feeding cycle. Examines insulin secretion, glucagon elevation, ghrelin oscillations, leptin signalling, and growth hormone dynamics during different phases of temporal eating patterns.
Learn more about metabolic phasesKetone Production During Extended Fasting Periods
Biochemical analysis of ketogenic metabolism activation during prolonged nutrient restriction. Explores acetyl-CoA accumulation, ketone body synthesis pathways, and the transition from glucose dependency to ketone utilisation in peripheral tissues.
Explore related metabolic conceptsAutophagy Activation: Timing and Triggers in Humans
Scientific examination of autophagy induction during fasting, cellular degradation processes, and the proposed mechanisms linking temporal eating to cellular renovation. Reviews evidence from human studies and mechanistic animal model research.
Continue to related timing conceptsEnergy Substrate Switching in Time-Restricted Patterns
Analysis of metabolic fuel switching from carbohydrate oxidation through glycogenolysis and gluconeogenesis toward lipid oxidation and ketone utilisation. Explores metabolic flexibility and the temporal progression of substrate transitions.
Read the full scientific explanationHistorical Perspectives on Intermittent Abstinence from Food
Cultural and scientific history of periodic fasting practices across diverse traditions and time periods. Contextualises contemporary time-restricted eating research within broader historical frameworks and subsistence realities.
Learn more about metabolic phases